Dumfries & Galloway Health Board
Prescribing Support Team

Nostrum Extra Angiotensin ll Receptor Antagonists

Posted: 6 Jun 06 Edited: 8 Aug 18
Nostrum Cardiovascular

Much has been written about the choice between ACEIs and ARBs. In patients with chronic heart failure or high risk acute MI, ARBs and ACEIs do not differ in outcome for all cause mortality (1.

Both agents have similar effects on mortality and renal outcomes in diabetic nephropathy.(2)

However, ACEIs significantly reduce all cause mortality compared with placebo but ARBs do not.

The evidence base for ACEIs in heart failure is much more extensive than ARBs.

ARBs should be reserved for those cases where an ACEI is indicated but not tolerated